I have a problem with Reaper (most recent version) and rtpMIDI - I'm using rtpMIDI to connect a drum controller software (MidiPads, which is great btw) on my iPad to control Addictive Drums on Reaper 4.22 (Windows XP Pro SP3). Whenever I select MIDI inputs and outputs for live routings in rtpMIDI, they become inaccessible in Reaper - I get a MIDI error message whenever I want to enable them under MIDI devices in Reaper's Preferences ("the following MIDI input could not be opened"). It's so frustrating. Everything works great in Cubase 5.