Steindork, Thanks for responding. I deleted the old reaper-midihw.ini, but the crash happened again. Same project. MIDI output stops, clicking in the upper right corner to get the Preferences dialog, Reaper freezes. Task Manager says "Not responding". Trying to close Reaper I get XP's "The program is not responding" message. This time, there are no warnings from the MIDIsport in the event viewer. And nothing but good-looking entries there. No crash dumps generated, even though I've set (and then restarted) [HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Contro l\CrashControl] to enable crash dumps and to write a small memory dump. Also, the MiniDumpDir key is set to %SYSTEMROOT%\MiniDump, but this dir does not exist (it would have been created, right? And yes I know %SYSTEMROOT% is C:\Windows). Something is rotten... I never saw this with 2.5x... Speaking of 2.5x, it may be relevant that this project was originally created in 2.57.